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Internal communication : Provide details and a link to the ARRIVE guidelines in internal communications for research staff conducting animal experiments e. A manifesto for reproducible science.

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Nature Human Behaviour. PLOS Biology. PLOS One. Surge in support for animal-research guidelines. Reporting of preclinical research in Anesthesiology: transparency and enforcement. Bias in the reporting of sex and age in biomedical research on mouse models. Where have all the rodents gone? The effects of attrition in experimental research on cancer and stroke. Robust research: Institutions must do their part for reproducibility.

Revision of instructions to authors for pharmacology research and perspectives: enhancing the quality and transparency of published work. PLOS Biology 13 5 : e BJP is changing its requirements for scientific papers to increase transparency. The National Institutes of Health and guidance for reporting preclinical research. The Journal of Pathology. Quality of reporting of interventional animal studies in rheumatology: a systematic review using the ARRIVE guidelines.

Refinement of experimental design and conduct in laboratory animal research. Open science and reporting animal studies: who's accountable? The need for randomisation in animal trials: an overview of systematic reviews. Is animal research sufficiently evidence based to be a cornerstone of biomedical research? Some salt with your statin, Professor? Retrieved 14 June Retrieved 7 July Times Of India. While growth has leveled off and there have been significant reductions in some countries, the number of animals used in research globally still totals almost million a year.

Nuffield Council on Bioethics. Retrieved 10 December Journal of Medical Ethics. In , the Laboratory Animal Breeders Association estimated in testimony before Congress that the number of mice, rats, guinea pigs, hamsters, and rabbits used in was around 60 million. House of Representatives, , p.

Understanding Animal Research. The principles of humane experimental technique Special ed. Indian Journal of Pharmacology. Tissue Engineering Part C: Methods. Archived from the original PDF on 7 June The Drum.

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Retrieved 23 July Nature Reviews Genetics. Immunological Reviews.

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Infection and Immunity. Adler B ed. Bibcode : PLoSO Bibcode : PNAS.. Bibcode : Sci Nature Cell Biology. Scientific American. Bibcode : SciAm. Nature Genetics. UK Home Office. British government. Retrieved 6 August Report from the Commission to the Council and the European Parliament. Retrieved 9 July International Primate Protection League. Conlee, Erika H. Hoffeld and Martin L. Fleur, Nicholas 12 June Will Call All Chimps 'Endangered ' ". New York Times. American Journal of Primatology.

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ILAR Journal. The Observer. National Center for Research Resources. Archived from the original on 22 September Animals, Property, and the Law. Temple University Press, , p. Senate Committee on Commerce, 25 March American Society for the Prevention of Cruelty to Animals. Journal of Animal Science. New York: Oxford University Press, , pp. Animal Cognition. ScienceDaily, 10 August Parliamentary Counsel Office. Retrieved 23 January Michigan State University.

Retrieved 25 January Encyclopedia of Animal Rights and Welfare. Greenwood Publishing Group, pp. University of Minnesota. Laboratory Animals. Archived from the original PDF on 15 August See chapter 3: "The purpose and nature of animal experiments. Journal of Biochemistry and Molecular Biology. The Anatomical Record. Philosophical Transactions of the Royal Society B. Trends in Genetics. WormBook : 1—4. Animal Science Journal. Retrieved 25 April Retrieved 30 January Developmental Dynamics. Diabetic Medicine. Nature Reviews Cancer. Veterinary Immunology and Immunopathology.

Cancer Investigation. Laboratory Animal Science. Annals of the New York Academy of Sciences. Frontiers in Bioscience.


European Journal of Endocrinology. Clinical Transplantation. Archived from the original PDF on 27 February The Journal of Pharmacology and Experimental Therapeutics. Environmental Health Perspectives. Survey of Ophthalmology. Current Opinion in Allergy and Clinical Immunology. Pro-Test Italia. Trends Pharmacol. PLoS Biol. Scientific Reports. Bibcode : NatSR The World Post. Archived from the original on 18 March Humane Society of the United States.

Archived from the original on 11 March Retrieved 27 February The Times of India. Retrieved 14 October Journal of the American Veterinary Medical Association. Why Dissection: Animal Use in Education. Westport: Greenwood Press. The Human Use of Animals. Oxford University Press. Atlanta Journal Constitution. Pacific Standard. The Physicians Committee for Responsible Medicine. Archived from the original on 22 July Retrieved 9 April BBC News. Retrieved 9 November Retrieved 10 November BBC News Magazine. The Washington Post. Archived from the original on 15 December Boston Globe.

Theoretical Medicine and Bioethics. Pew Research Center. Blackwell Companions to Philosophy, Academic Emergency Medicine. Bart; Sena, Emily S. PLoS Med. Nature Medicine. The New York Times. The Journal of Physiology. Microscopy Research and Technique. Nature Biotechnology. Journal of Neurophysiology. Retrieved 6 July Archived from the original on 1 August Retrieved 16 December An animal welfare perspective".

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Canadian Council on Animal Care in Science. International Journal of Medical Sciences. Archived from the original on 9 December BfR 30 September Retrieved on Michael and Parker, James V Experimenting with humans and animals: from Galen to animal rights. Speaking of Research, Historical Statistics for animal research numbers , accessed 19 April Animal testing. Animal testing Alternatives to animal testing Animal testing on invertebrates Animal testing on frogs Animal testing on non-human primates Animal testing on rabbits Animal testing on rodents Experimentation on prisoners History of animal testing History of model organisms Laboratory animal sources Toxicology testing.

Animal rights Animal welfare Pain and suffering in laboratory animals Biomedical research Great Ape research ban International trade in primates.

Charles River Laboratories, Inc. Animal testing Animal rights Animal welfare. However, the experiments performed on the rats in the Yu et al. This should not have been published. The second, huge problem with this particular rat model is that such treatments do not induce depression. Instead, they induce extreme stress. I can only imagine the fear that these animals must have felt when they heard the door of the animal facility open.

The extreme physical and neurological demands and anxiety induced in these animals are very different than the persistent sadness and loss of interest that are associated with human depression. So the findings of these experiments will have very little, if any, value for patients diagnosed with depression. The third flaw with this paper is that it does not make much sense to test the effect of depression on the fecal composition in an animal model.

Instead, the authors could have studied stool samples from human depression patients and compared these to stool from healthy controls. Taking these concerns together, this study used disproportionally inhumane animal suffering to study something that has no value for human health, and that could have easily been performed in humans. I would like to call upon the Editorial Board of the Journal of Pharmaceutical and Biomedical Analysis , and Elsevier, the publisher, to consider to retract this paper.

Studies that include torturing of animals without any scientific reason should not be published. I also very much hope that both editors and peer reviewers will be on the lookout for manuscripts that include this or other similarly awful type of animal experiments. Thresholds of the amount of acceptable animal suffering clearly differ from country to country. During my searches for image manipulations, I have regularly seen experiments in which live mice are dipped in boiling water, sewn together, or allowed to walk around with tumors as big as their own body.

An approval by an institutional committee does not necessarily mean that peer reviewers and editors should find such animal experiments acceptable too.

Animal testing

We can and have to push back on useless studies where the amount of animal suffering goes much beyond what is acceptable in the name of science. Note: Retraction Watch has contacted the corresponding author of the paper, as well as the publisher of the journal, Elsevier, who told us the handling editor is looking into the matter. Like Retraction Watch?

It would have been accepted in a high impact journal, fit very well with the current zeitgeist and received a good reception from the microbiomics community. But it would have most likely been interpreted as bad microbiome causing depression. This could have led to a protracted, expensive and ultimately futile effort to fix the microbiome to cure depression. The correlation study which can be done without animals should be a necessary prerequisite for the animal study. That is not a solution. Unfortunately, these authors only learned from the best.

The horrific picture of a rat coming out of its own calcified skin was not perceived as cruelty; on the contrary, it was a major scientific breakthrough. Not clear, though, if all that animal suffering was for any benefit to very rare human patients with calciphylaxis. I have served for years on our institutional animal welfare committee and occasionally we deal with protocols that use animal models of depression, which make use of procedures such as forced swimming in warm water!

All of these protocols receive extensive scrutiny and have to be backed up by a strong scientific rationale. Procedures like the ones described in Yu et al would have zero chance of being approved. Ethical use of animals in research requires a judgement of the balance between the harms done to the animals and the benefits accruing from the research.

On a practical note, journals simply cannot review the judgements of every ethics committee for every piece of work. The techniques used here are used not infrequently to model certain aspects of human diseases including aspects of depression. Of course, depression is a human disease and so a model can only ever be a model, but they can be instructive none the less.